Does Neuroprotection Prevent Epileptogenesis?

Neuroprotection and Anti-Epileptogenesis with Mitochondria-Targeted Antioxidant

Neuroprotection does not work!

For more than 2 decades neurologists have searched for a drug that protects ischemic brain tissue from cell death— without success so far. The list of drugs tested in phase II and III trials is long. One of the first substances that showed a neuroprotective effect in experimental ischemia was the NMDA-antagonist MK-801,1 which protected hippocampal CA1 and CA2 pyramidal neurons. Besides NMDA an...

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.

Epigenetic modifications, including changes in DNA methylation, lead to altered gene expression and thus may underlie epileptogenesis via induction of permanent changes in neuronal excitability. Therapies that could inhibit or reverse these changes may be highly effective in halting disease progression. Here we identify an epigenetic function of the brain's endogenous anticonvulsant adenosine, ...

Does acquired epileptogenesis in the immature brain require neuronal death.

Because epilepsy often occurs during development, understanding the mechanisms by which this process takes place (epileptogenesis) is important. In addition, the age-specificity of seizures and epilepsies of the neonatal, infancy, and childhood periods suggests that the processes and mechanisms that culminate in epilepsy might be age specific as well. Here we provide an updated review of recent...

Does inhibition of angiotensin function cause neuroprotection in diffuse traumatic brain injury?

Objective(s): Neuroprotection is created following the inhibition of angiotensin II type 1 receptor (AT1R). Therefore, the purpose of this research was examining AT1R blockage by candesartan in diffuse traumatic brain injury (TBI). Materials and Methods: Male rats were assigned into sham, TBI, vehicle, and candesartan groups. Candesartan (0.3 mg/kg) or vehicle was administered IP, 30 min post-T...